"Randomized Crossover Trial of a Modified Ketogenic Diet in Alzheimer's Disease" (Phillips et al., 2021)

Dr. Lee "Next is the fourth paper on the keto diet and dementia: "Randomized Crossover Trial of a Modified Ketogenic Diet in Alzheimer's Disease" (Phillips et al., 2021).

This crossover study randomly assigned 26 patients with Alzheimer's disease into two groups. Crossover means they switched. One group started with the ketogenic diet for 12 weeks, then a 10-week standard-diet washout, then another 12 weeks of keto. The other group began with a 12-week standard diet, followed by 10 weeks of keto, and then 12 weeks of standard again. Group assignment was random. Of the cohort, 81% (21 participants) completed the 12-week ketogenic phase.

Three measures gauged dementia outcomes: ADCS-ADL for daily-life function, QOL-AD for quality of life, and ACE-III for cognition. As Figure 6-7(a) shows, ACE-III improved more in the keto group than the standard-diet group. ADCS-ADL daily function also showed greater change in the keto group (Figure 6-7b). And QOL-AD scores rose in the keto group as well (Figure 6-7c)."